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ID9286
Title Medical Reports & Case Studies
E ISSN 2572-5130
P ISSN
Country Belgium
Impact Factor Awaiting
Publication year 2016
Publisher NameInternational Online Medical Council (IOMC)
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Website https://www.iomcworld.org/medical-reports-case-studies.html


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begin to recover until the 16th century.

The Black Death era is the perfect opportunity to look at the effects of humans on biodiversity over a longer period, Jonathan Gordon, a paleoecologist at the Leverhulme Centre for Anthropocene Biodiversity at the University of York and first author of the paper, told Live Science.

In the study, which was published March 4 in the journal Ecology Letters, the researchers compared more than 100 European pollen records that included about 4,600 samples. The records came from sites ranging from the lowlands of France and uplands of the southwest United Kingdom to the Swiss Alps.

The pollen records "give us information on the past diversity of the plant records," Gordon said.

For example, cereal grains ‪—‬ such as wheat, barley and rye ‪—‬ were a fundamental part of medieval agriculture. The representation of pollen from these types of crops in the pollen record points to historic land use.

The researchers divided the pollen data into three categories based on the presence of cereal pollen: places where agricultural production went up, places where it went down, and places where there was no evidence of cereal cultivation.

"We found a decline in biodiversity overall, but the decline overall was driven by those landscapes that declined in agricultural production," Gordon said.

"In those landscapes where agricultural production went down, there was a reduction in biodiversity of around 40%. Then, after about 150 years, as populations started recovering and landscape disturbances started increasing again, biodiversity went up to slightly above the level it was before."

Mosaic landscapes

Many people think there was a "stable and pristine world in which the entry of people has only one result: net loss of species and homogenization," Erle Ellis, an agroecologist at the University of Maryland, Baltimore County who was not involved in the research, told Live Science in an email. "The paleoecologists have always known the story is far more complicated."

There is a growing body of evidence showing that people's long-term cultural shaping of their landscapes often creates more diverse habitats, known as "mosaics," that can sustain more species than simple homogenous landscapes can, he said.

Whereas modern agriculture focuses on single crops on plots of land, in previous centuries, "you had all these different types of agriculture operating within the same landscape," Gordon said.

"In that landscape, you had lots of natural features that remained from the Middle or Early Holocene (which began after the last Ice Age about 12,000 years ago)," he added. "You had old bits of woodland, you had heaths, you had ponds, and bits of secondary forest. It was all interlaced with these agricultural mosaics, and that led to raised biodiversity because there were more habitats for different plant species to exploit."

A row of tractors ride through dirt fields

Modern farming often uses monoculture, where one crop species is grown over a large area. This lowers biodiversity in the area. (Image credit: alffoto via Getty Images)

The findings highlight the differences between medieval and modern land use practices — and their consequences for biodiversity. Research suggests that during the 20th century, global biodiversity declined by up to as much as 11% and human activities‬, such as land-use changes, pollution, and climate change‬, are the major culprits. In agriculture, the practice of monoculture — where a single crop species is grown over a large area — reduces biodiversity.

"What this work contributes to showing is that, until relatively recently, even in Europe, very different forms of land management and interaction were practiced than exist today," Patrick Roberts, director of Department of Coevolution of Land Use and Urbanisation at the Max Planck Institute of Geoanthropology, told Live Science in an email.

"Rather than the monoculture, plantations, or uniform changes to landscapes we see in the 20th and 21st centuries, emphasis was placed on maintaining 'mosaics,'" said Roberts, who was not involved in the new research.

In the study, "we can see how relationships between people and biodiversity have changed through time and how people can actively use landscapes while maintaining biodiversity and mixed ecosystem functions," he said.

There is still more to understand about how humans' disappearance from landscapes in the Black Death era affected the natural world, Gordon said. "There are a lot of other types of diversity ‪—‬ not just the number of types, but what the different types present actually do." There may be a hundred types of plants in a landscape, but if they do the same thing, "you have low functional diversity," he said.

Functional diversity "is super important for how ecosystems adapt to changes in climate and how resilient they are, which is something we need for future-proofing our agricultural system," Gordon said.

'> Black Death had dramatic effect on species diversity as humans abandoned farmland, study finds Timothy Cunningham, an assistant professor of astronomy and astrophysics at the University of Warwick who led an international team of researchers to study the object, said in a statement.

SN 1181 is one of only five supernovas in the Milky Way galaxy known to have been witnessed from Earth before the invention of the telescope. (Those optical instruments first appeared in the Netherlands in 1608.) Now, advanced ground-based telescopes can produce wonderfully detailed images of those historic remnants. This latest image is from the Gemini North telescope on Mauna Kea in Hawaii and reveals about 10 times more filamentary structures in Pa 30 than have been seen before. This extraordinary detail gives astronomers fresh clues about the unusual explosion and the environment surrounding the star.

"These images give us the clearest picture yet of Pa 30's structure, and it's not what we expected," said Cunningham, whose team published their findings in The Astrophysical Journal. "The filaments are made of chains of tiny knots rather than smooth streaks, providing new constraints on the nature of the space around the star before it exploded and the physical processes that have shaped the expanding ejecta."

The knot-like structures may have resulted from variations in temperature or density in material surrounding the star as debris from the explosion expanded.

Pa 30 contains another unusual feature: a surviving star that sits almost exactly at the center of the remnant. That's highly unusual, because a supernova explosion typically sends stars away from their original positions. It suggests that the original explosion was highly symmetrical, the researchers said.

Furthermore, Pa 30 is thought to be a Type Iax supernova. Unlike standard Type Ia supernovas, which destroy their stars, a Type Iax event is a lower-energy, incomplete explosion of a white dwarf star that can leave behind a remnant known as a "zombie star." It's the only Type Iax supernova ever found.

'> This 850-year-old 'firework' supernova is full of mysterious knots

A calculated hunter

Cuttlefish are visual hunters, using their large, complex eyes to locate and track potential meals. In general, their strategy involves a slow, stealthy approach, said Bret Grasse, the manager of cephalopod operations at the Marine Biological Laboratory in Woods Hole Massachusetts.

"The cuttlefish will slowly approach the prey so as to not alert the unsuspecting shrimp, fish or crab," Grasse told Live Science in an email.

During their approach, cuttlefish often put on a showy display, producing moving bands across their body. These displays are produced by a combination of light-reflecting pigment cells known as iridophores, leucophores and chromatophores. These cell types contract and expand to produce specific colors and patterns, all within milliseconds.

Some may wonder whether this trick can mesmerize prey, but scientists don't think that's the case.

Hypnosis, defined as a mental state of increased relaxation and altered awareness, is thought to be a uniquely human psychological state. There is very little research on whether fish can be hypnotized, but a 2005 study found that pushing a steady stream of water through the snapper (Chrysophrys auratus) put them in an immobile state similar to being hypnotized. Another study looked at sedative hypnotic drugs like benzodiazepines and barbiturates and their effects on zebrafish, finding that the fish had molecular receptors for these drugs, which helped render them immobile. However, whether fish can be visually put into a state like hypnosis has yet to be directly studied.

And while some animals, such as chickens, can be induced into trance-like conditions of tonic immobility, an involuntary, temporary state of unresponsiveness that happens when humans or animals experience extreme trauma, it's unlikely that the cuttlefish's color changes "hypnotize" their prey, Connor Gibbons, the cephalopod facility manager at Columbia University told Live Science. Instead, some researchers believe that the color show serves as an ingenious disguise.

As waves of different colors ripple down the cuttlefish's body, the shape of the animal becomes less obvious to its prey, so they may not see the cuttlefish as a threat to flee from, Gibbons said.

"It's only part of something looming at them, which they're like, 'I don't know if you are a predator? Are you just passing waves? What are you?'" Gibbons said. "And then by that time, it's too late."

A cuttlefish uses its tentacles to capture a shrimp (Image credit: Oxford Scientific Films via Getty Images)

Once they get close enough, the cuttlefish shoots their two long, specialized feeding tentacles from small hidden pouches near the animal's mouth at their prey.

"The closest thing I can compare it to is the tongue of a chameleon extending out to grab an unsuspecting insect," Grasse said. "Cuttlefish feeding tentacles will fire out in the blink of an eye before the prey can react and escape."

Then, the prey is pulled toward the cuttlefish's mouth, pierced by its sharp, chitinous beak and injected with venom. The use of the venom helps the cuttlefish reduce their energy usage when hunting "as the cuttlefish does not want to use unnecessary energy and struggle against the prey while it's trying to eat," Grasse said.

However, the notion that cuttlefish flash colors to hide their body shape is only one idea of why cuttlefish perform these strobing color displays. Other researchers, including Grasse, describe them as a way to distract their prey.

"Essentially, they are trying their best not to alarm the prey to their presence," he said. By breaking up the size of their bodies, cuttlefish can convince their prey they're not as large or alarming as they may seem.

Whether the light shows are for disguise or distraction still needs parsing out, Gibbons said, and scientists also need a better understanding of how the cuttlefish controls its deadly dermal display. "The jury is still out on exactly what is happening," he said.

How much do you know about octopuses? Find out with our octopus quiz!

'> Can cuttlefish hypnotize their prey? historically mild weather. In recent decades, their range has contracted significantly. But climate change is threatening the health and function of these forests.

The region has seen significant warming in recent decades, and faces more frequent extreme heat days, with temperatures spiking above 100 degrees Fahrenheit (37 degrees Celsius). Now, in a new study, published Sept. 22 in the journal JGR Biogeosciences, a team of researchers has shown that California's renowned redwoods are struggling to photosynthesize in the heat.

Photosynthesis is the process used by plants, algae and some bacteria to turn sunlight into energy. It chemically converts carbon dioxide and water into sugars and oxygen.

"These trees adapted to grow in really temperate environments, so no one had really looked at the impact of heat on photosynthesis," study first author Lily Klinek, a doctoral candidate in the Plant Optics Lab at the University of California, Davis, told Live Science.

From 2022 to 2024, Klinek and colleagues measured how the leaves of redwoods in Garcia River Forest in Mendocino County responded to the heat. Once or twice a month, the researchers took three different California redwood leaf samples and measured their fluorescence and temperature.

A plant's molecules can use absorbed light in three ways: for photosynthesis, dissipated as heat, or reflected as light (florescence). Fluorescence is a proxy measurement to understand photosynthesis in the plant, Klinek said.

The researchers wrapped a fourth leaf in tinfoil for 20 minutes to put it in a state of "rest" before taking the same measurements. "When they're in a state of rest, we expose them to a pulse of light that’s in the wavelength they would use for photosynthesis to see what would be their maximum photosynthetic rate," Klinek said.

They found that on hot days, the leaves exposed to sunlight were up to 18 degrees Fahrenheit (10 degrees Celsius) hotter than the air temperature. "That's a huge difference and indicates that the leaves are stressed to the point where they can't thermoregulate effectively," Klinek said.

Many plants' leaves manage their temperature and photosynthesis by opening or closing their stomata, which are tiny pores on their surface. These stomata (from the Greek word for mouth) regulate the amount of carbon dioxide entering the plant, and how much oxygen and water vapor it releases. Lower carbon dioxide intake leads to reduced photosynthesis, meaning the plant has less energy.

The large differences between air and redwood leaf temperatures suggest that the leaves had closed their stomata to avoid losing water from evaporation during hot conditions and consequently overheated, Klinek said.

To further investigate the impact of heat on leaf physiology, the researchers took California redwood leaf samples back to the laboratory and exposed them to a range of temperatures while they were in water. Despite their access to water, the leaves still photosynthesized less as they got hotter, even though their stomata were open, Klinek said.

This shows that heat imposes direct limitations on redwood photosynthetical capacity, rather than indirectly decreasing that capacity by causing stomatal closure, the researchers wrote. The finding indicates that redwoods' ability to photosynthesise and store carbon will decrease as temperatures rise.

​​"It is not only stomatal closure that is causing reduced photosynthesis," Lucy Rowland, an ecologist at the University of Exeter in the U.K. who was not involved in the study, told Live Science in an email. "These trees are already suffering from the direct effects of heat on their photosynthetic systems."

The finding has serious implications for the future of redwoods and similar plants. "The points at which this damage becomes irreversible remains really poorly understood, but is something which is really essential to understand if we want to predict how our future climate is going to impact plants," she said.

The next step in Klinek's research is to move beyond leaf physiology to understand these thresholds on the trees and their ecosystems as a whole.

"We're not sure to what extent the effect that we saw is a reversible stress response and if they are sustaining damage from this constant stress," she said. Researchers need more data to "really get a better sense, beyond the leaf scale, how these ecosystems are responding to heat and drought," she added.

'> California redwoods are struggling in the heat — and it's not clear how much damage is being done

A blue and red swirl of embryo showing two different cell types.

This photograph shows a 9.5-day-old mouse embryo and depicts the two separate developmental origins of the brain. The forebrain and part of the midbrain (blue) express the Otx2 gene, while the hindbrain and the rest of the midbrain (red) express Gbx2. The red cell population also extends into the spinal cord. (Image credit: Stanford Medicine)

The functions of these genes were already known, but their distinct expression in these two groups of cells was revealed by the new research. The cell populations remained distinct as they developed into full-fledged nervous tissue, rather than overlapping.

The team also examined chromatin, the molecular structure that packages DNA tightly inside the nucleus and helps regulate which genes a cell can use. The two cell populations show different chromatin configurations, the team found, which further supports the idea that they follow separate developmental pathways.

That may help to explain why scientists' attempts to grow hindbrain neurons have been largely unsuccessful.

"Previous attempts to make hindbrain neurons likely tried to coax forebrain and midbrain progenitors into hindbrain cells, which our study shows is not possible," study co-author Rayyan Jokhai, a graduate student in Loh's lab, said in a statement.

Why it matters

Using the information uncovered in their experiments, the researchers successfully guided human stem cells to transform into functional hindbrain motor neurons, which are involved in controlling movement. Specifically, these cells produced proteins characteristic of the hard-to-grow hindbrain regions that help control muscles of the face and those involved in swallowing.

In several neurological diseases, including spinal muscular atrophy and amyotrophic lateral sclerosis, motor neurons deteriorate and affected patients can lose their ability to swallow, speak and breathe independently.

"We cannot sample living motor neurons from a patient's hindbrain to watch how these diseases attack these neurons," Loh said. "Growing these hindbrain motor neurons in a dish gives us a way to investigate these diseases." Looking forward, the team aims to use their findings to study these diseases and pinpoint new treatments.

The new findings could also reveal something fundamental about the evolution of vertebrate animals.

The study authors investigated whether the two developmental pathways were unique to humans or reflected a much older evolutionary arrangement. They turned to previously published data on other species — including macaques (Macaca), zebrafish (Danio rerio) and chickens (Gallus gallus domesticus) — and again found two distinct cell populations expressing the two key genes.

And even in acorn worms — a marine invertebrate whose evolution diverged from vertebrates about 550 million years ago — they again found these two distinct groups of cells.

"The Stanford discovery establishes that the deep ancestry of the vertebrate brain is fundamentally modular," said Anna Di Cosmo, a professor of biology at the University of Naples Federico II in Italy who wasn't involved with the study. "The developmental separation between the anterior lineage (forebrain/midbrain) and the posterior lineage (hindbrain) is traceably ancient," Cosmo told Live Science in an email.

Loh's team speculates that these developmental trajectories seen in the womb may suggest that the two cell populations once belonged to two separate nervous systems. "Later in evolution, these two nervous systems may have been pushed together to give rise to the appearance of one integrated brain," Loh said.

However, the study doesn't reveal exactly when the two pathways arose or establish how they integrated. "It is important to emphasize that this is only an idea, and it might change as scientists learn more," Loh said.

See how much you know about the most complex organ in the human body with our brain quiz!

'> Is the brain actually 2 nervous systems smooshed together? A new study claims it is.
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