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Title Creative Saplings
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Country India
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Publication year 2022
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The findings, published Oct. 23 in the journal Science Immunology, also point to a potential way to block that pain.

"Inflammation in the gut has always been thought of like a fire: the sensory nerves alarm because of the smoke and the heat, and when the fire is put out the alarm should stop," said study co-author Dr. Heng Xu, a physician at Ninth People's Hospital in Shanghai. Xu and his colleagues set out to try to isolate what could be causing the pain even when there's no visible "fire" or "smoke."

"What we found is that the tissue itself changes consistency," Xu told Live Science in an email. "It becomes stiff and less elastic, a bit like a scar, and that stiffness alone keeps triggering the alarm even after the fire is out."

In ulcerative colitis, the most common form of IBD, inflammation causes ulcers in the gut, as well as symptoms like bloody diarrhea and abdominal cramping. Several medications can help quell this inflammation, but that doesn't necessarily eliminate patients' pain. The researchers wondered if immune cells that live in the gut might contribute to that ongoing pain.

They zoomed in on a protein called Piezo1; in immune cells, it's known to play a role in inflammation, and in neurons, it contributes to pain signals. The team looked at whether this protein's activity changed in the context of colitis.

"We started with sequencing data that reads cells one at a time, from the gut tissue of patients with ulcerative colitis and from mice with the disease," Xu said. "One cell type stood out: an immune cell that lives permanently in the gut wall, rather than arriving from the bloodstream when there's trouble." The quantity of these cells was higher in colitis than in healthy guts, and the cells carried more Piezo1 than the other cells analyzed.

"They sit touching the nerve endings," Xu added.

In several experiments with lab mice with colitis, the team used a probe to press on the gut tissue and measure how hard it was. This showed that, compared with healthy mice, the gut was stiffer in two models of disease: one with visible inflammation and another with almost none.

They also measured pain levels in both sets of mice. "In mice with almost no visible gut inflammation, the pain was still there, which is why a colonoscopy can look normal while the patient hurts," Xu said.

They then looked at Piezo1 in both sets of mice. The protein sits in the immune-cell membrane, and when the stiffened tissue around it is pulled or squeezed, it's as if a button were pressed and a channel opens, Xu said. This sets off a chain reaction that leads to pain, Xu said.

That's because calcium ions rush into the cell via the channel, and that surge sends a protein called NF-kB from the cell's interior fluid into its nucleus — the control center where DNA is stored. There, NF-kB plugs into a gene, ordering the cell to manufacture nerve growth factor (NGF) that then exits the immune cell.

This NGF, which is known to amplify pain signals in the body, interacts with nearby pain-sensing neurons. These nerve endings grow denser and become hypersensitive, which makes ordinary gut activity painful, the study suggests.

This newly described mechanism could help explain why ulcerative colitis patients can sometimes contend with pain even when their colonoscopies look normal. (Image credit: Kinga Krzeminska via Getty Images)

The researchers used chemicals as on-off switches for Piezo1 in immune cells, opening the channel with one and closing it with another. As they did this, they tracked calcium signals and NGF production, and both rose and fell in step with the switch. This result suggests that Piezo1 activity is both necessary for this response and, on its own, enough to trigger it in these cells, Xu said.

Blocking this chain of events abolished the pain hypersensitivity in both sets of mice. The researchers tried completely removing the Piezo1 gene from the gut immune cells and found that this eliminated the pain. Removing the gene also caused no problems in healthy mice, they noted.

The study was "well controlled," said Hongzhen Hu, the scientific director for the Mark Lebwohl Center for Neuroinflammation and Sensation at the Icahn School of Medicine at Mount Sinai, who was not involved in the research. Future research should address the chemical messengers that coordinate inflammation, called cytokines, and determine whether the same chain reaction occurs in human cells, he said in an email.

The mouse experiments also may not reflect long-term, chronic disease in patients, given the mice experienced symptoms only transiently, Xu said.

Xu and his colleagues are now aiming to develop a drug that can target Piezo1 to switch off gut pain locally without suppressing the entire immune system. This would be a more targeted treatment than current options, such as immunosuppressants or opioids.

Other scientists have explored using anti-NGF treatments for other chronic pain conditions but not for ulcerative colitis, Xu noted. Fully blocking NGF might have downsides, he said, since NGF also helps to maintain nerves.

So more work is needed to translate these findings into a treatment. But for now, the work sheds new light on how immune cells can detect a physical change — such as tissue becoming stiff — and convert it to a pain signal.

"For the pain field, that's a conceptual shift," Xu said.

This article is for informational purposes only and is not meant to offer medical advice.

'> IBD may transform neurons in the gut, triggering pain even when inflammation is under control
  • 1 million-year-old skull from China holds clues to the origins of Neanderthals, Denisovans and humans
  • "It is still possible that there are some other lineages that existed in East Asia during the time Denisovans are known to have existed," study co-author Qiaomei Fu, director of the Ancient DNA Laboratory at the Institute of Vertebrate Paleontology and Paleoanthropology, part of the Chinese Academy of Sciences, told Live Science in an email.

    "We know from DNA that Denisovans were a very varied group genetically, which split early into different populations," Chris Stringer, a paleoanthropologist at the Natural History Museum in London who was not involved in the research, told Live Science in an email. "These could have developed a lot of morphological variation, which may well surprise us as the sample of fossils grows."

    The researchers also produced a new reconstruction of what a Denisovan man might have looked like. A previous DNA study suggested that Denisovans likely had dark skin, brown hair and brown eyes. The new reconstruction shows the Denisovan looking directly at the viewer, with his low, wide braincase mostly obscured by dark hair flowing back from his massive brow ridge. There are clear similarities between the Denisovan man and Neanderthals as well as modern humans, but the Denisovan has a distinct visage all his own.

    See how much you know about early humans with our human evolution quiz!

    '> Our extinct cousins the Denisovans had a 'distinctive' appearance, new analysis reveals

    An ultrasound revealed a calcified mass and an empty uterus. Calcification is a buildup of calcium that hardens tissue into a solid mass.

    To get a better look at the mass, which occupied the woman's lower abdomen and pelvis, the doctors ordered an advanced CT scan to create a 3D model. The imaging revealed that the mass contained clearly identifiable fetal skeletal structures, including a skull, a spinal column, ribs, and arm and leg bones. The mass measured roughly 7 by 5 inches (18 by 13 centimeters).

    The diagnosis: Doctors concluded that the woman had a lithopedion, or "stone baby." The term comes from the Greek words "lithos," meaning stone, and "paidion," meaning child.

    In a typical pregnancy, an egg is fertilized in a fallopian tube — the structure between the ovaries and the womb — and then travels into the uterus, where it implants in the uterine lining. By contrast, lithopedions most often start as abdominal pregnancies,‬ a type of ectopic pregnancy in which the embryo instead implants on the lining of the abdominal cavity.

    There, the embryo shares the space with organs like the stomach, kidneys and appendix. These misplaced pregnancies are almost never viable and are highly life-threatening for the mother. Because the placenta attaches directly to delicate abdominal organs and blood vessels, these carry a severe risk of catastrophic internal bleeding.

    If the fetus dies at a developmental stage when it is too large for the mother's body to naturally break down and absorb, her immune system can sometimes treat the retained tissue as a foreign object. To protect the mother from inflammatory complications and infection, the body progressively deposits calcium over the fetal remains, creating a protective casing. In this case, the calcified fetus likely accounted for the woman's chronic abdominal pain and increasing sense of heaviness, her doctors concluded.

    The treatment: The doctors performed abdominal surgery to completely remove the calcified fetal mass from the woman's pelvis.

    The day after surgery, she developed a mild fever and nausea, but both resolved with treatment. She remained stable and improved during her hospital stay before being discharged in good condition.

    Follow-up visits over the next six months showed she had healed well, with a complete resolution of her abdominal pain.

    What makes this case unique: Only about 340 cases of lithopedion have been documented in the medical literature over the past 400 years, with the earliest documented in 1582.

    This woman's case stands out because she was 42 years old, while many recent cases have been diagnosed in postmenopausal women. (Women typically experience menopause around 51 to 52 years old.) In these cases, the initial ectopic pregnancy occurred during the woman's childbearing years, but she unknowingly carried the calcified remains for decades before developing symptoms. For example, a 74-year old woman from India carried her "stone baby" for more than three decades. By contrast, the woman's recent case was caught after only three years.

    The case also highlights the challenges of maternal healthcare in resource-limited settings such as Somaliland, where a lack of access to routine prenatal care and early pregnancy scans can lead to delayed diagnoses. That said, the successful use of advanced 3D imaging and complete surgical recovery demonstrate that excellent outcomes are possible even in these constrained environments, the doctors noted.

    For more intriguing medical cases, check out our Diagnostic Dilemma archives.

    This article is for informational purposes only and is not meant to offer medical advice.

    Can you guess the diagnosis in these strange medical cases? Find out with our diagnostic dilemma quiz!

    '> A woman carried a 'stone baby' in her abdomen for 3 years

    In practice, the more likely outcome is darker: AI will not simply sweep away the bureaucratic machinery of universities; it will give that machinery a new regime of AI compliance — more policies, more forms, more trackers, more oversight roles and more work downloaded onto faculty who are already stretched thin.

    The danger is not that AI will destroy universities but that universities will use AI to preserve the very processes that make them dysfunctional. If this happens, we might see faculty spending less time on research, less time on teaching, and more time on activities that do not directly contribute to the production of knowledge and education of students.

    This is already evident in the existing assessment system in the U.K., but shades are creeping into systems elsewhere, providing a window into the future for U.S institutions. A single piece of student work may pass through a plagiarism-detection platform, a grading interface, a moderation spreadsheet for faculty to share feedback, a grade-transfer system, and an exam-board record. Each stage generates its own logins, deadlines, exception rules and audit trails. None of this is inherently malicious. Anonymous marking, moderation, appeals, accessibility and academic integrity are legitimate concerns. But when each concern is implemented as a separate system, the combined effect is administrative incoherence.

    In essence, faculty become the human interface between incompatible platforms, spending their time reconciling grades and chasing missing evidence rather than teaching. While this example pertains to U.K. universities, the trend to expand the administrative staff extends to North America. AI simply introduces a new opportunity to increase administration.

    AI could, in principle, solve this. It could integrate systems, automate routine reporting, draft feedback, identify inconsistencies and remove duplicate data entry. Yet the institutional incentive is rarely to remove work; it is to make work visible. A university that automates a broken workflow does not necessarily simplify it. It may simply produce faster reports about the broken workflow, more sophisticated dashboards and more elaborate evidence of compliance. The bureaucratic impulse survives by changing its vocabulary: risk management, assurance, transparency, governance, responsible innovation.

    At least one possible outcome is that universities will create AI-use policies, require module-level AI statements, mandate disclosure forms, introduce approved-tool lists and establish review committees. Faculty will be asked to redesign assessments, monitor suspected misuse, document their decisions, complete training, and explain their approach to students. Much of this labor will be invisible. It will appear not as a new job title but as an additional expectation attached to teaching.

    When something goes wrong, the academic is exposed; when the system works, the institution claims the credit. That asymmetry is corrosive.

    This creates a familiar pattern: responsibility without authority. Faculty are expected to make consequential judgments about academic integrity, fairness, privacy and assessment validity. But they do not control procurement, system design, institutional policy or disciplinary procedures. When something goes wrong, the academic is exposed; when the system works, the institution claims the credit.

    That asymmetry is corrosive. It teaches committed staff that careful judgment is not valued as expertise but rather as a compliance risk to be managed, and the consequences will fall unevenly. Experienced faculty, after voicing their concern to no avail, may leave, retire early or disengage. Early-career academics, already precarious because they don't have tenure, will have the least power to resist. Students will receive less of the resource that matters most: sustained intellectual attention.

    One possible outcome is that universities will encourage the development of faculty AI avatars and cut hours and employment. The institution will then justify hiring more ‪—‬ not fewer ‪—‬ compliance and "educational enhancement" staff to manage and maintain these AI avatars, negating the idea of efficiency and cost savings. In this scenario, bureaucracy will expand to manage the problems created by its own expansion while undercutting quality for the students who are paying high tuition fees. One might need to hire staff for oversight of these avatars, administrators and lawyers to manage licensing agreements, quality control staff in case things go wrong, and IT teams for integrating them into learning platforms and websites.

    There is an alternative to the administrative tasks. AI should be governed by a simple institutional rule: no new compliance requirement without the removal of an equivalent existing burden. If a university requires assessment redesign to accommodate AI, or the introduction of new technology, it should provide protected time, technical support and a single integrated platform. If it expects faculty to manage AI use, it must give them clear institutional backing rather than leaving them to improvise. And critically, it should show how the technology makes work more efficient before rolling it out across the board.

    But the deeper issue is not technology but institutional purpose. A university exists — or should exist — to cultivate understanding, judgment and intellectual independence. If its systems consume faculty time, fragment the student experience, and reward documentation over learning, then AI becomes another instrument of managerial self-preservation. The question is not whether universities can adopt AI. It is whether they can resist using AI to automate their own absurdities.

    If they cannot, the outcome will be an educational system that looks progressively sophisticated while becoming increasingly hollow ‪—‬ full of monitoring, low on trust; rich in measuring, poor in teaching; obsessed with compliance, indifferent to the people who make education possible; overly procedural sans intellectual life. It will become an audited theater of learning not worth students' time.

    Opinion on Live Science gives you insight on the most important issues in science that affect you and the world around you today, written by experts and leading scientists in their field.

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    '> Universities should not be adopting AI to automate their own absurdities
  • 'There's a sense that these algorithms are objective and they get to know you': How social media warps our understanding of healthcare
  • The research, presented at the 2026 Conference on Language Modeling in San Francisco earlier this month, found that people who relied on AI assistance for tasks like math problems and reading comprehension were more likely to give up or struggle when the assistance was taken away. The findings suggest that leaning too heavily on AI could weaken people's motivation to push through challenges.

    The research raises the question of what happens when people stop exercising their brains. So do you think AI is making you less motivated, or even "dumber," or is it simply making you more efficient? Vote in our poll, and let us know your thoughts in the comments.

    '> Is AI making you lazier?
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