Journal List
ID7963
Title Journal Of Methodology Of Social Sciences And Humanities
E ISSN 2588-5774
P ISSN 1608-7070
Country Iran
Impact Factor Awaiting
Publication year 1995
Publisher NameResearch Institute of Hawzah and University (RIHU)
FrequencyQuarterly
Indexed Yes
Website http://method.rihu.ac.ir/


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The Voynich manuscript is a medieval codex made up of leaves of parchment carbon-dated to the early 15th century. Its 240 pages are covered with about 38,000 words of a unique script called "Voynichese" along with illustrations of people, plants and astrological symbols. Also known as the Beinecke Cipher manuscript, the document was initially owned by a Holy Roman emperor and was purchased by Wilhelm Voynich in 1912. Since 1969, the manuscript has been in the collection of Yale University's rare book library. Experts have unsuccessfully tried to decipher the manuscript for more than a century.

"We don't know if it's a code," Lisa Fagin Davis, study co-author and executive director of the Medieval Academy of America, told Live Science. "But there are some odd characteristics of the Voynich manuscript in terms of its physical structure."

When doing research on the number of scribes who copied the document, Davis realized from the handwriting that the manuscript's pages alternate in ways that don't make sense. In addition, she said, "there are several examples where the image goes off the page in the middle and comes out on the other side, even though there are a bunch of pages in between."

In a study published Monday (Oct. 19) in the journal Digital Medievalist, Davis and co-author Colin Layfield, an information systems researcher at the University of Malta, suggested that the inconsistent structure of the enigmatic manuscript is the result of someone mis-binding a manuscript they were unable to read.

a series of illustrations of how the Voynich manuscript may have been misbound

An illustration of how the Voynich manuscript may have been bound incorrectly. (Image credit: Quinn Reynolds for Live Science)

Medieval manuscripts were made up of rectangular sheets of parchment (animal skin), typically folded in half to produce what experts call a bifolium. Around five bifolia would typically be nested together, creating what experts call a quire. Then, a stack of quires would be bound together along the spine to create a book. However, Davis and Layfield suggested that the Voynich manuscript was intended to be a stack of singulions — a series of loose bifolia never meant to be bound together as a quire or a book.

This is not the first time a researcher has suggested the Voynich manuscript has pages out of order. But Davis and Layfield analyzed the graphic properties of the untranslated document to see if their hypothesis made sense.

"We're viewing it as a text and assuming it has a message," Layfield told Live Science, which means it should be possible to statistically compare blocks of text to see if they're similar or disconnected. Layfield used a technique called latent semantic analysis (LSA), which is a natural language processing technique invented in the 1980s to find hidden patterns in texts.

LSA is particularly useful for small sets of data, Layfield explained. "Modern AI techniques need ridiculous amounts of data to train on, which we just don't have. We've got just 35,000 or so words. That's it." The researchers' LSA analysis of the Voynich manuscript revealed that some pages had low similarity, suggesting they may not have gone together, while others had high similarity, bolstering the idea that they were supposed to be read together.

By looking at the Voynich manuscript as a collection of singulions, Davis and Layfield solved some of the nagging issues with the document.

"When you start to think about it in the context of the other strange features of the manuscript, all of those problems are resolved," Davis said. "It solves the problem of each scribe writing one sheet. It solves the problem of the images crossing the gutter."

This means that any previous work on the Voynich manuscript that assumes it was ordered correctly now needs to be reconsidered, she said, but it also means there is new progress on the book.

"This work helps us think about whether there's actual meaning underneath it all," Davis said. "It doesn't get us there," she said about a definitive translation, "but it moves the ball because you can't make sense out of a book where all the pages are mixed up."

Davis is optimistic that someone will crack the Voynich mystery, in part because a similar modern puzzle known as Cain's Jawbone has been successfully deciphered by a handful of people. This devilishly difficult linguistic puzzle from the 1930s consists of 100 pages of a murder mystery arranged in the wrong order. Due to the unique nature of the text and its vague, stylized language, even AI has failed to solve it.

"We have some ideas for other work we want to do," Davis said. For example, there's a large water stain in the upper margin of some of the pages of the Voynich manuscript. "The stain should be symmetrical from one page to the next but it's not. That also supports the idea that the manuscript is bound out of order."

Davis and Layfield are thinking about ways to compare the stain shapes across the pages, as that may help them reorder the incorrectly organized pages.

See if you know what these mysterious artifacts are with our archaeological fragments quiz!

'> Undeciphered Voynich manuscript may have been bound out of order, study finds

Delusions are false beliefs that are very difficult to shake; for example, a person might believe they are being stalked when they aren't or think that a major disaster is about to occur without any evidence to suggest so. In the trial, researchers found that a 10-minute session of the ultrasound treatment reduced the severity of delusions for at least a week in patients with schizophrenia or a related disorder.

This targeted ultrasound treatment delivered directly to the brain could avoid some of the full-body effects of antipsychotic medications, such as weight gain and high blood pressure. That said, the new results, published Tuesday (Oct. 20) in the journal npj Acoustics, are a first step and will need further verification in larger trials.

"It's too early to know for certain what the therapeutic benefits will be, but it's very exciting," study co-author Dr. Donald Goff, a professor of psychiatry at the New York University Grossman School of Medicine, told Live Science.

Targeting deep brain structures

The pilot study included 10 patients with either schizophrenia or schizoaffective disorder. In both conditions, patients experience psychotic symptoms, including delusions and hallucinations. Schizoaffective disorder also includes mood symptoms, such as mania.

The researchers interviewed each participant to characterize the content of their delusions, and also documented their cognitive state and experiences with auditory hallucinations — perceptions of sounds that aren't actually occurring. The participants then received both an ultrasound treatment and a placebo treatment, spaced one week apart.

Other noninvasive therapies — such as transcranial magnetic stimulation, which uses magnetic fields — can also stimulate the brain. But the ultrasound technique differs from these therapies because ultrasound waves can penetrate deeper into the brain with greater specificity, study co-author Shy Shoham, a neural engineer at NYU Grossman, told Live Science. He compared the way a transducer directs ultrasound waves toward a given brain region with the way a lens focuses light.

In this case, the researchers focused this lens on a brain network called the cortico-striatal-pallido-thalamic circuit, which includes structures underneath the brain's outer cortex. The relationship between this circuit and schizophrenia symptoms is still somewhat unclear, partly because its deeper components are hard to study in adequate resolution with MRI, said co-author Dr. Wei Qi, a clinical assistant professor of psychiatry at NYU Grossman. However, some past studies have suggested that this network plays a part in schizophrenia.

The ultrasound treatment targeted a brain structure called the globus pallidus internus (orange). (Image credit: SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY via Getty Images)

Much of what scientists know about the network comes from research in movement disorders, such as Parkinson's disease, in which there is an imbalance between excitation and inhibition in the neurons that control movement. A similar dynamic could help to explain symptoms of schizophrenia, the scientists think.

"Our hypothesis is that, in schizophrenia, there is an imbalance between excitation and inhibition regarding what in the environment is actually important," Qi told Live Science. "The failure to inhibit irrelevant signals could be the basis of psychosis."

"Quite optimistic"

The researchers surveyed the study participants after each treatment, asking about the degree of belief each person had in their delusions and the amount of stress they caused. Compared with the placebo treatment, the ultrasound stimulation was associated with less-severe delusions over the following week. There was no significant change in patients' auditory hallucinations or overall cognition, though.

The ultrasound therapy came with mild side effects, such as fatigue and headache. Some patients had transient increases in delusions, which Qi attributed to normal fluctuations in symptoms that are expected in schizophrenia. These outcomes were just as common after the placebo treatment, so they may not be related to the ultrasound specifically.

The stimulation was aimed specifically at the right side of a brain structure called the globus pallidus internus (GPI). In a previous study, the authors found that greater connectivity between this region and another structure — the dorsal anterior cingulate gyrus — was linked to more-severe psychotic symptoms in schizophrenia. So, they made the GPI their target.

To date, "there haven't been many successful therapeutic attempts at targeting some of these deeper structures," said Dr. Deepak Sarpal, an associate professor of psychiatry at the University of Pittsburgh School of Medicine who was not involved with the study. Ultrasound waves reach brain regions under the cortex in a less-invasive manner than deep brain stimulation, in which a surgeon implants an electrode in a patient's brain, Sarpal noted.

The researchers are not the only group using transcranial ultrasound to influence the cortico-striatal-pallido-thalamic circuit. Earlier this year, another group stimulated portions of the striatum, which is located directly under the cortex, in patients with schizophrenia. They evaluated hallucinations rather than delusions, finding that the treatment reduced symptoms for at least a week after the procedure.

In this line of research, the targeted nature of transcranial ultrasound presents advantages as a research tool as well as a treatment approach.

"If we find that a specific circuit or a node in a circuit seems to be closely linked to symptoms we're trying to treat, then it will be a matter of understanding what pattern of stimulation may allow us to correct that," Goff said. Qi, Goff and colleagues now plan to continue testing their technique on more patients and to experiment with different doses of ultrasound.

"A lot more work needs to be done," Goff said, "but we're really quite optimistic about its promise."

This article is for informational purposes only and is not meant to offer medical advice.

See how much you know about the most complex organ in the human body with our brain quiz!

'> Ultrasound waves that jiggle deep brain structures may relieve delusions in schizophrenia, small trial hints Land and sea surface temperatures during one of Europe's record-breaking summer heat waves

Which satellite took the photo? Sentinel-3B

When was it taken? June 23, 2026

This striking satellite snap shows the scorching land and sea surface temperatures that hit Southern Europe during one of the continent's record-breaking heat waves this summer.

The image was created using data from the Sea and Land Surface Temperature Radiometer (SLSTR) on board the European Space Agency's (ESA) Sentinel-3B satellite. It was selected for this week's edition of Earth from space by Simonetta Cheli, director of Earth observation programs at ESA and head of the European Space Research Institute (ESRIN) in Frascati, Italy.

Live Science recently visited Frascati to see ESRIN's newly operational Space HPC supercomputer and sat down with Cheli for an in-depth discussion about Earth observation. When asked about her favorite satellite image, Cheli highlighted this photo as one that caught her eye this year.

In the thermal image, dark reds highlight terrestrial temperatures in excess of 95 degrees Fahrenheit (35 degrees Celsius) across most of Spain and parts of France and Italy, while dark purple spots show highs above 104 F (40 C) across patches of Spain and North Africa. The image also reveals sea surface temperatures spiking across the Mediterranean Sea. (The colors in the image do not represent the same temperatures on land and sea. For example, orange indicates temperatures of around 86 F (30 C) on land but around 73 F, or 23 C, at sea.)

Cheli said that assessing how terrestrial and marine environments interact during extreme weather events is really important and that including both in the same image is the only way to appreciate the true scale of this heat wave: "You see the red in the sea, and you see the red on the land, and I think it gives the feeling of the heat wave that we've all been living through this summer," she said.

A photo of the Sentinel-3C satellite launching on board a rocket in September

ESA launched the Sentinel-3C satellite in September, on board a Vega rocket that lifted off from the agency's launch site on French Guiana. It will help the agency monitor future extreme weather events in even greater detail. (Image credit: European Commission)

While many people may find such images related to human-caused climate change disheartening, Cheli sees it as a sign of hope that orbiting spacecraft can monitor otherwise-invisible changes to our planet's surface in such detail.

"It makes me feel that we can do a lot about it," she said. "It makes me feel that we have tools and certainly information capabilities to support, help and also raise awareness about this topic."

Cheli told Live Science that ESA's ability to monitor extreme weather events like this will only improve as the agency launches new-and-improved spacecraft into orbit. In September, ESA successfully launched Sentinel-3C, the successor to the spacecraft that snapped this image, which has already captured its first photos of Earth and will help study future heat waves in greater detail.

Europe's record-breaking summer

Between late May and mid-August, parts of Europe were hit by at least five separate heat waves, meaning temperatures stayed unusually high throughout the season. "We had, I would say, the hottest summer ever," Cheli said.

The peak heat occurred in June, when the average temperature for that month reached 69 F (20.7 C) — its highest in Western Europe's recorded history, according to the World Meteorological Organization. (This average includes nighttime temperatures, which is why it seems relatively low compared to other temperatures mentioned so far.)

Eight countries — Austria, Belarus, Czechia, Denmark, Germany, Hungary, Poland and Slovakia — recorded their highest land surface temperature of all time at various points throughout this summer, and several others had record temperatures for a specific month or region.

The extreme weather caused widespread droughts across the continent, some of which are still ongoing, and helped trigger several wildfires, including a series of particularly large blazes in France. Experts think the high temperatures resulted in at least 35,000 excess deaths across Europe, although the true number is expected to be much higher, according to The Guardian.

A photo of Simonetta Cheli stood next to an interactive model of the globe

Simonetta Cheli is the director of ESA's Earth observation programs, and has been working at the agency for nearly 40 years. She described this summer's heat waves as the hottest she can remember. (Image credit: ESA)

The heat waves were caused by "heat domes," which are pockets of high pressure in the atmosphere that trap warm air beneath them, like placing a lid on top of a boiling pot. These are also linked to higher sea surface temperatures.

The ongoing super El Niño began in May and has already led to record temperatures in the Pacific Ocean, but it did not contribute to the European heat waves, according to ESA. Instead, the record temperatures are a continuation of recent global warming trends.

However, El Niño could lead to more extreme weather this winter, in Europe and in North America.

See more Earth from space

A satellite photo showing tens of thousands of small fields tightly crammed around a river in Taiwan

Multicolored agricultural 'mosaic'

A recent satellite photo shows a patchwork of tens of thousands of size-restricted farms tightly crammed into Taiwan's Yunlin County, which grows a majority of the island's food.

Photo of a space shuttle with an open cargo bay over the Bahamas

Space Shuttle's final photobomb

This 2011 astronaut photo captured one of NASA's iconic space shuttles passing between Earth and the International Space Station for the very last time.

A beautiful light blue plume swirling in the sea off Key West

Polar vortex paints picturesque plume

A recent satellite photo captured a stunning scene of sediment swirling across the West Florida Shelf after an extreme cold snap that covered large parts of the eastern U.S. in snow.

'> 'It makes me feel that we can do a lot about it': ESA official shares striking satellite snap of Europe's record-breaking summer heat waves climate change, as environmental degradation, food insecurity and extreme weather events can all reveal themselves in stark images taken from high above our planet's surface.

Simonetta Cheli is the director of Earth observation programs at the European Space Agency (ESA) and the head of the European Space Research Institute (ESRIN) in Frascati, Italy. With nearly 40 years of experience in the field, she is one of the world's leading experts on Earth observation.

Live Science spoke with Cheli on a recent visit to ESRIN to talk about why Earth observation is so important, how NASA budget cuts and political changes have altered the picture, and why private space satellites risk our ability to view the planet clearly.

Live Science spoke with Cheli on a recent visit to ESRIN to talk about why Earth observation is so important, how NASA budget cuts and political changes have altered the picture, and why private space satellites risk our ability to view the planet clearly. She also discussed how new supercomputers, like ESRIN's newly operational Space HPC, are helping to process vast amounts of data like never before — and shared her favorite recent satellite snap of our planet

A headshot of Simonetta Cheli

Simonetta Cheli became ESA's director of Earth observation programs and head of ESRIN on Jan. 1, 2022, more than three decades after joining the agency. She was born in Siena, Italy, and went on to study law and economics at Yale University before gaining a degree in political sciences at the University 'Cesare Alfieri' in Florence, Italy. She also holds a diploma of advanced studies from the Centre d’Etudes Diplomatiques et Stratégiques in Paris. (Image credit: ESA)

Harry Baker: Why is observing Earth from space so important?

Simonetta Cheli: It's important because we need to know today what is the state of our planet, if it's healthy or if it's in danger, if it's stressed or not.

It's important to have objective information on many different variables, such as deforestation, the quality of the air that we breathe, the evolution of the oceans or the melting of ice masses. Basically, we need to be aware of what the situation is on Earth today, so we can preserve it tomorrow.

HB: How has ESA's Earth observation program changed throughout your career?

SC: When I started at ESA [in 1988], we were relying on missions from partners, including the Americans and Japanese. We didn't have our own missions.

We launched the first mission [ERS-1] in 1991. Today, just here at ESRIN, we manage over 20 missions and are planning more than 40 more. We have also launched three different missions in the last three weeks — one to look at how oceanography impacts extreme weather events [International Report for an Innovative Defence of Earth]; one to monitor the fluorescence and health status of vegetation [Fluorescence Explorer]; and one to measure temperature on land and sea [Sentinel-3C], which was a super useful thing this summer.

A photo of Simonetta Chelli speaking at a podium

Cheli is one of the world's leading experts on Earth observation and currently oversees more than 20 different missions that are monitoring our planet from above. (Image credit: ESA)

Europe is now a leading power in this domain worldwide. We have evolved a lot.

HB: How important is it to cooperate with other countries when observing our planet from above?

SC: Well, I must say, in ESA, it's in the DNA of our work. ESA includes 23 countries today, so we work together daily. We also work very closely with other commercial partners and the European Union, as well as international partners like NASA, Brazil, India and Africa. So this is part of our job, and very much also in the domain I'm managing.

We used to go to the climate conferences together. We are not anymore.

Simonetta Cheli, ESA

To tackle climate and environmental stability, you cannot just do things alone at the national level. You have to share data and work with everybody in the world, where you have to have common objectives. For example, what happens to Greenland affects everybody on Earth, not just the people who live there. So the collaboration, I think, is very much inherent in our daily job at ESA and between our partners.

HB: Given the recent cuts to NASA's funding, including its Earth observation budget, does ESA feel a bigger responsibility to step up and fill the gap?

SC: I think we certainly have a bigger opportunity in the sense that today, with the systems we have and the satellites we have and the missions we have, even before the political context. For example, we were already leading the U.S. with data on emissions.

A photo of an ESA sign and model rocket at the entrance to the ESRIN center in Frascati

Live Science recently visited Frascati to see ESRIN's newly-operational Space HPC supercomputer. (Image credit: Harry Baker/Live Science)

We have a very good working-level collaboration with our American partners. This is somehow preserved, although politically it is, of course, more delicate. We used to go to the climate conferences together. We are not anymore.

HB: ESA just launched the latest batch of satellites in the IRIDE constellation (an Italian funded network of Earth-observing spacecraft designed and operated by ESA). What makes these satellites so special? And how are they helping your research?

SC: We launched the latest eight [satellites] last night! (The IRIDE satellites launched on Oct. 1, the day before this interview took place.)

Sixty-eight satellites are planned overall in this constellation, and we have launched quite a few [39] already, and plan to launch some more before the end of the year.

A photo of the Sentinel-3C satellite launching on board a rocket in September

On Sept. 14, ESA also launched the Sentinel-3C satellite on board at Vega rocket that lifted off from the agency's launch site in French Guiana. (Image credit: European Commission)

The network will collect a lot of data from the optical radar spectrum that will support different user needs: for example, in the civil protection area, in coastal erosion monitoring, in coast guard operations and in environmental stress analysis. And so this system will certainly be a big contribution to the wider European Earth observation setup.

HB: The number of private satellites, like in SpaceX's Starlink constellation, is increasing fast. Are you worried about the impacts that this might have on your scientific spacecraft?

SC: We are worried because we see that the anti-collision maneuvers are increasing and increasing. When my mission manager tells me we have to move the satellite because there is a risk of collision with another satellite, we have to go check with ESO [European Southern Observatory] in Germany, and then the operations center moves the satellite. And the number [of times we've done this] has certainly increased in the last four or five years due to the increased number of satellites up there.

For the moment, the technical collaboration with partners is going quite well. So when we see someone else's satellite, we actually try to organize things as best we can, and technically it's working well. But what we need for the future is a clear framework at the legal level, which is engaging everybody.

"Everybody" in space is no longer only the institutional partners; it's not just the space agencies of the world that should engage. Today, you have private actors, like Starlink, and if they don't engage in the same rules, you risk having a delicate situation. But this is something that we are discussing daily, and we're tackling.

HB: The whole point of Earth observation is to protect our planet. How do you feel about some of the negative impacts of launching satellites, such as exhaust plumes, metal pollution and space junk?

SC: There is a very strong objective linked to sustainability at ESA. It is not just about using the data to better preserve our planet; it's also about being sustainable in the daily work we do.

A photo of Simonetta Chelli stood next to a model of the globe

Chelli has been working at ESA for nearly 40 years, and believes that global cooperation is essential in Earth observation. (Image credit: ESA)

This is linked to, for example, trying to have a space debris policy; trying to have enough propellant on board of the satellites that we build to make sure that once they finish their lifetime, they come back with a re-entry assist and they don't stay there in orbit. And the same is true in the launcher domain, where there's a very strong effort from our partners in French Guiana [where ESA's only active launch site is located] to lessen our impact as much as possible on the environment with the launch setup.

There's a really dedicated team doing all this.

HB: How will AI systems and advanced computers, like Space HPC, help researchers process data? And what sort of things could that help you do?

SC: We have today a wealth of data that is continually increasing. Just in the Copernicus program [Europe's biggest Earth observation initiative], we receive 500 terabytes of data per day.

We also have big volumes of data in the archives here at ESRIN from science missions of international partners, including Japan, India, the U.S. and others. This "heritage data" guarantees that archival data of missions that have ended are preserved, which is super important.

A photo of Simonetta Chelli (red coat) stood next to other ESA officials at the opening of the Space HPC supercomputer in Frascati

Chelli (center right) was one of the people chosen to cut the ribbon at the opening of ESRIN's Space HPC supercomputer on March 12, 2025. (Image credit: ESA)

So instruments like SpaceHPC, which have high computing capability, help us a lot to process those datasets faster.

HB: What is your favorite satellite photo of Earth?

SC: I have too many favorite satellite photos, I must say. But this summer, the one I really found striking was a thermal image of Europe's heatwaves because, in that image, you see that the temperature on land and on sea was increasing so much.

A multicolor thermal photo of Southern Europe showing high temperatures across the continent

This photo, captured by ESA's Sentinel-3B satellite in June 2026, shows land and sea surface temperatures spiking across Southern Europe. While it is concerning, Cheli says that the image gives her hope about our ability to monitor such extreme weather events in the future. (Image credit: ESA/Sentinel-3B)

It was captured by Sentinel-3B [a predecessor of the recently launched Sentinel-3C], and you see the red in the sea, and you see the red on the land, and I think it gives the feeling of the heat wave that we've all been living through this summer. We had, I would say, the hottest summer ever.

But it makes me feel that we can do a lot about it. It makes me feel that we have tools and certainly information capabilities to support, help, and also raise awareness about this topic.

So right now that is a favorite, but there are so many [other photos].

This interview has been condensed and edited for clarity.

'> 'We used to go to the climate conferences together. We are not anymore': ESA official Simonetta Cheli tells us how the political landscape for Ear...

The Orionid meteor shower will peak overnight Wednesday (Oct. 21) through Thursday (Oct. 22), potentially producing around 20 meteors per hour under a dark sky, according to Time and Date. The Orionids are caused when Earth passes through the debris left by Halley's Comet, which last passed through the inner solar system in 1986 and will return in 2061.

Halley's Comet is presently beyond the orbit of Neptune, according to The Planets Today, but it doesn't need to be close to Earth to cause "shooting stars." Every time the comet travels through the inner solar system, heat from the sun causes it to shed dust and rocky particles along its orbital path. Earth's own orbit takes the comet through streams of that ancient debris several times a year, with the particles vaporizing as they slam into our planet's atmosphere.

The Orionids are particularly fast meteors, striking Earth's atmosphere at around 41 miles per second (66 kilometers per second). They can produce bright streaks, occasional fireballs (extremely bright, sometimes colorful meteors) and "persistent trains" — glowing trails that remain visible briefly after a meteor has disappeared. The best way to view them is with the naked eye, although a nice pair of stargazing binoculars or a small backyard telescope will help you enjoy more sights during peak skywatching season this fall.

Halley's Comet produces not one but two annual meteor showers. Its orbit comes close to Earth's at two different points, so our planet encounters the comet's debris twice each year — once during the Orionids in late October, and again during the Eta Aquariid meteor shower in early May.

There's a slight complication with the Orionids this year. A 71%-illuminated waxing gibbous moon will brighten much of the night, making it harder to spot meteors. However, the moon will set early Thursday morning, creating a valuable window of darkness before dawn. That's also when the constellation Orion will be high in the sky, making the predawn hours the best time to watch.

You can trace the paths of Orionid meteors back to their radiant: the famous red supergiant star system Betelgeuse in the constellation Orion. (That's why the shower is called the Orionids.) However, there's no need to look directly at Orion. Meteors seen farther from the radiant can produce longer streaks across the sky; each one comes from a tiny piece of Halley's Comet completing a journey that began many centuries ago.

'> See pieces of Halley's Comet fall to Earth this week as the Orionid meteor shower peaks
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