Journal List
ID6731
Title Journal Of Toxicology: Current Research | Issn:
E ISSN 2639-3735
P ISSN -
Country USA
Impact Factor Awaiting
Publication year 2017
Publisher NameHerald Scholarly Open Access
FrequencyAnnual
Indexed Yes
Website http://www.heraldopenaccess.us/journals/Toxicology-Current-Research/


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executive order on childhood vaccines has generated a predictable and understandable debate around public health needs, parental autonomy and the scientific justifications for the directive. The order proposes, among other things, altering the U.S. childhood vaccine schedule and splitting up the combined MMR vaccine into multiple shots. As an immunologist, my view is that the order contradicts established scientific consensus and instead backs narratives that are not supported by evidence.

However, the more important issue with the order may be something more fundamental: What happens when vaccine policy is divorced from the scientific processes designed to guide it?

For many decades, the U.S. relied on a transparent process in which scientists, physicians, public health experts and vaccine specialists reviewed evidence and developed recommendations for who should receive a given vaccine and when. Through this process, there would be disagreements, which is not only expected but welcomed. Constructive debate on policy can lead to the development of better policies. But replacing expert scientific review with political directives risks creating a precedent that extends well beyond vaccines.

It's very possible that the immediate impact of the executive order will be limited. Many pediatricians, state public health agencies and professional medical organizations are likely to continue following established immunization schedules that were developed through decades of scientific review and real-world experience. The order itself does not magically change how vaccines work, how doctors practice medicine, or how states set school vaccination requirements.

Indeed, while the order says a lot, it doesn't hold direct authority to change vaccine recommendations. These, at least for now, are still protected by federal laws. The order can set direction but not policy.

Nevertheless, it would be a mistake to conclude that the order does not matter, because the true risk it poses is that it creates confusion and uncertainty for parents and caregivers, who only want to protect their children as best they can.

Vaccination programs rely on something fragile: the public's confidence. This confidence can be destroyed easily. Parents deserve to have trustworthy information when making decisions about the health of their children. Physicians, too, must trust that vaccine schedules reflect the best available science. Weakening those foundations of trust will further contribute to declining vaccination rates, even if no formal mandates change.

We are seeing this right now. U.S. kindergarten vaccination rates have continued to drop, falling farther below the thresholds needed for herd immunity. This is especially concerning at a moment when the U.S. is experiencing one of its worst measles outbreaks in decades, while other preventable infectious diseases are making a resurgence.

The executive order proposes separating the combined measles, mumps and rubella (MMR) vaccine into three individual vaccines — and this illustrates the problem. The proposal is framed as part of an effort to reduce the number of childhood immunizations, but it would do the opposite in practice.

Here's why. Today, during their first years of life, children receive two doses of the combined MMR vaccine, administered in two separate injections. Under the approach outlined in the executive order, children would need six separate injections to achieve the same protection.

The changes to the childhood vaccination schedule proposed in the executive order are not backed by scientific evidence. (Image credit: adamkaz via Getty Images)

The order also suggests that each immunization be administered at separate medical visits, thus tripling the number of visits needed to reach the same protection. For families, that translates into more time away from work, more missed school, more transportation costs, more co-pays for those whose insurance plans require them, and more opportunities for appointments to be postponed or missed altogether.

These practical consequences shouldn't be ignored. Every additional visit creates another chance for a child to fall behind on vaccinations. Every added logistical hurdle disproportionately affects families with fewer resources, less schedule flexibility or less access to healthcare.

What's more, the separate vaccines required to implement this policy are not even currently available in the U.S. Manufacturers would need to develop new production processes, conduct testing, navigate regulatory review and establish distribution systems for these separate vaccines, all to replace a combined vaccine with an extraordinary record of safety and effectiveness spanning more than half a century.

In short, the proposal would require substantial new costs and complexity just to replace a system that has been working exceptionally well and protecting children for decades. The combination MMR vaccine was developed precisely because combining vaccines reduces the number of injections, thus improving vaccination rates by ensuring children receive protection as early and efficiently as possible.

What matters more is whether recommendations are supported by evidence and whether they effectively protect children in America, specifically.

What is the rationale behind the executive order? Administration officials have pointed to differences between U.S. vaccine recommendations and those from some other developed countries, such as Denmark, which recommends fewer routine vaccines than the U.S. does. On the surface, that argument may sound reasonable — if another country administers fewer doses, why shouldn't the U.S.?

The answer is that the timing and number of vaccines are developed to suit different countries' wildly different healthcare systems and public health realities. Countries differ in disease prevalence, healthcare access, vaccination delivery systems, screening programs and population demographics. Some countries have more centralized healthcare systems that allow for easier preventive care follow-up, while others face different infectious disease risks than the U.S.

It is therefore unsurprising that schedules vary among nations, and the motivation to match other countries' schedules is arbitrary, rather than science-led. What matters more is whether recommendations are supported by evidence and whether they effectively protect children in America, specifically.

It may be months or years before we see the consequences of this executive order and the wider attacks on vaccines. It will be reflected through declining confidence in public health institutions, growing uncertainty among families, and increasing difficulty in maintaining high vaccination rates, leading to higher rates of disease and death.

That is why this executive order matters.

Whether formal policy changes will be implemented now or in the future is less the issue. What's more at stake is whether the order will drive Americans to rely less on scientific evidence and expertise when they're making decisions that affect their children's health.

I believe immunology is one of the critical scientific infrastructures that underpins modern medicine. Vaccine policy should be built on the foundations of that infrastructure, with the science and evidence guiding public health recommendations. When this fails, the results will be measured in the lives lost to preventable illness, and that's a future we must avoid.

This article is for informational purposes only and is not meant to offer medical advice.

Opinion on Live Science gives you insight on the most important issues in science that affect you and the world around you today, written by experts and leading scientists in their field.

'> Trump's childhood vaccine order will threaten children's safety, even if it doesn't directly change policy

The moon won't fall totally under Earth's shadow, so we can't officially call it a "blood moon," but it will be the deepest lunar eclipse anywhere in the world until the next total lunar eclipse on Dec. 31, 2028.

Why does the moon turn red during a lunar eclipse?

A lunar eclipse happens when the moon passes directly behind Earth and falls into its shadow. But instead of going completely dark, the moon turns a deep shade of coppery red. This is because of the way Earth's atmosphere absorbs and bends light.

Sunlight is made up of a spectrum of colors. The blue and yellow parts of this spectrum are absorbed by Earth's atmosphere. But red light is bent, or refracted, by our planet's atmosphere and directed toward the moon, lighting it up like a blood-red flashlight beam, according to the European Space Agency.

The exact shade of red depends on what else is going on in Earth's atmosphere at the time. For example, volcanic ash and desert dust can significantly darken a lunar eclipse.

Unlike with a solar eclipse, you don't need eclipse glasses to safely see a lunar eclipse.

While the partial eclipse will be visible to the naked eye, even better views are possible if you use one of the best telescopes, best smart telescopes or best stargazing binoculars. If you're looking to photograph the moon, check out our picks for the best astrophotography cameras to capture the best shots of the lunar eclipse.

'> The moon is turning red tomorrow night — here's why, and how to watch continues to fall among kindergarteners and as the proportion of kindergarteners with vaccine exemptions is rising. The U.S. is likely to lose its "measles elimination status" later this year, which would mean the same outbreak strain had been consistently circulating in the country for over 12 months. Essentially, this suggests that although the U.S. officially eliminated measles in 2000, the disease is likely back in regular circulation.

The U.S.'s vaccination rate for measles has steadily declined recently. (Image credit: FatCamera/Getty Images)

According to the tracker, nearly all of the measles cases reported this year — 96% — have been among unvaccinated people or people with unknown vaccination status. Two doses of either the MMRV vaccine (which protects against measles, mumps, rubella and chickenpox) or the MMR vaccine are about 97% protective against measles infections. (Both vaccines offer the same protection against measles, but the latter excludes protection against varicella, or chickenpox. Kids who receive the MMR shot get a separate chickenpox vaccine.)

Measles infections can cause rash; fever; cough; runny nose; and red, watery eyes. About 1 in 5 unvaccinated people who catch measles are hospitalized, and there's a risk of developing complications like pneumonia or brain inflammation. In the U.S., 1 to 3 in 1,000 people with measles die of the disease. Those who survive the infection can develop long-term health problems, such as neurological disease or "immune amnesia," where the immune system loses ability to fight off pathogens it's encountered in the past.

"Because measles was largely eliminated in the Commonwealth for more than three decades, people are not familiar with this disease and don't fully understand the potential severity of the illness," Dr. Debra Bogen, Pennsylvania's secretary of health, said in the statement. "We want to ensure every Pennsylvanian has the information they need to protect themselves, their loved ones and their communities."

The best way to protect against measles is to get fully vaccinated, DOH representatives said in the statement.

This article is for informational purposes only and is not meant to offer medical advice.

'> 2 people die of measles in Pennsylvania as vaccination rates drop across the nation

a ground penetrating radar image of a circular ditch

A remote sensing image of a Neolithic period enclosure found in the Czech Republic. (Image credit: University of West Bohemia)

Sun and moon

The shape and orientation of the mysterious structure are unusual for a Stone Age site, the archaeologists noted.

"Circular enclosures are completely unknown in our region for this period, which already makes the site exceptional," Petr Krištuf, an archaeology professor at the University of West Bohemia in the Czech Republic who is leading the research team, said in the statement. "But when we began to analyze the positioning of the entrances in detail, it became clear that their arrangement was not random. Their geometry creates a system that made it possible to observe the most significant moments of the solar and lunar cycles."

Specifically, the 12 entrances were oriented so that people inside the enclosure could observe important astronomical events, such as the moon's most extreme position on the horizon during its 18.6-year cycle. People could also observe sunrise on the summer solstice, the longest day of the year, and sunset on the winter solstice, the shortest day of the year, through the structure's entrances.

"For prehistoric farming communities, the connection between sunrise and the summer solstice symbolized a beginning, while sunset and the winter solstice represented an ending," Krištuf said. "The same principle can be seen along Stonehenge's main axis. We can now see that [this site] was designed similarly."

In later times, the ritual purpose of the Chleby structure seems to have changed or been lost entirely. Previous excavations at the site found burials of 18 people from the Bronze Age Únětice culture (circa 2300 to 1600 B.C.), a culture which had unique burials and artifacts, including the Nebra Sky Disc. The site may have still maintained a ritual purpose at this time. But in the Iron Age (circa 800 B.C. to 1 B.C.), a settlement was built over the Chleby site.

"By the Iron Age, the monument appears to have definitively lost its original significance. The ditch was gradually filled in, and an ordinary settlement was established on the site of the former sanctuary," Krištuf said.

Research is ongoing, and archaeologists plan to analyze the site's soil to learn more about the people who once lived there.

"In addition to artifacts and the remains of the dead, people leave chemical traces in the soil. These can help us understand how this exceptional site was used during different periods of prehistory," Jan Fišer, an archaeologist at the University of Hradec Králové in the Czech Republic who is involved in the research, said in the statement.

What do you know about the Paleolithic, Mesolithic and Neolithic eras? Find out with our Stone Age quiz!

'> Ritual solstice structure 1,000 years older than Stonehenge unearthed in Czech Republic A "sunglint" shining off the ocean and the island's lake

Who took the photo? An unnamed astronaut on board the International Space Station

When was it taken? Jan. 8, 2023

This eye-catching astronaut snap shows a rare phenomenon known as a "sunglint," which transformed a Pacific island into a pseudo-magnifying glass with a shining silver lens.

The uniquely shaped landmass is Rennell Island (also known as Mugaba or Mu Nggava), one of the southernmost of the Solomon Islands — an archipelago nation of nearly 1,000 islands, atolls and reefs that lies between Australia, Papua New Guinea and Fiji. It is up to 50 miles (80 kilometers) long and 8 miles (13 km) across at its widest point.

At the southeastern end of the island (right side of this photo) lies Lake Tegano (also known as Lake Te Nggano), a roughly 60-square-mile (155 square kilometers) body of brackish water, which is surrounded by a jagged ring of coral topped with dense forest. It is the largest lake on any Pacific island, according to Britannica.

In this photo, sunlight reflects off the surface of both the Pacific Ocean and Lake Tegano directly into the astronaut's camera, making the water appear metallic. This sunglint effect is the strongest on the lake's left side and a horseshoe-shaped bay on the island's bottom edge, because these areas are most sheltered from the wind and therefore have the stillest and most reflective surfaces, according to NASA's Earth Observatory.

Shadows from clouds are peppered across the sea's silver surface, adding an element of depth to the scene.

A photo of the sun setting on Lake Tegano

Lake Tegano is the largest lake on any of the more than 20,000 islands in the Pacific Ocean. (Image credit: Wikimedia)

Sunglints are useful to scientists because they can help reveal hidden oceanographic features, such as subsurface currents, oil slicks and internal waves, which look like marks on a mirror when this phenomenon is ongoing. Sunglints can also occur on land when sunlight reflects off rivers or illuminates large lakes.

However, the reflected sunlight can obscure parts of aerial images, making them a nuisance in certain tasks, such as hurricane tracking. As a result, sunglints are digitally removed from most satellite images, according to the National Oceanic and Atmospheric Administration (NOAA).

Rennell Island is an atoll, meaning it is built on top of the remains of an ancient coral reef, most likely left behind when another island sank into the sea long ago. Its highest point sits around 500 feet (150 meters) above the ocean surface, making it the tallest atoll in the world, according to Britannica.

A aerial photo of Rennell Island showing a fringing coral reef skirting its coastline

Rennell Island is surrounded by a fringing coral reef that completely disappears in the sunglint photos. (Image credit: Wikimedia)

The landmass is surrounded by a fringing coral reef, which can usually be seen in aerial photos as a light-blue or turquoise band around the atoll's edge. However, because of the sunglint, the reefs have disappeared from view in this image. Similarly, Lake Tegano has several small islands that can't be seen here due to the reflected sunlight.

The region surrounding Lake Tegano is a biodiversity hotspot and has been listed as a UNESCO World Heritage Site. This area, dubbed East Rennell, is home to more than 20 endemic bird species, as well as the Crocker's sea snake (Laticauda crockeri), which is vulnerable to extinction, according to the Earth Observatory.

See more Earth from space

'> Rare sunlight trick transforms Pacific island into a giant silver 'magnifying glass' — Earth from space
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