Journal List
ID5920
Title International Research In Medical And Health Sciences
E ISSN 2581-771X
P ISSN -
Country India
Impact Factor Awaiting
Publication year 2018
Publisher Nameyogesh kumar
FrequencyBimonthly
Indexed Yes
Website www.irmhs.com


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While research has long linked a scrambled circadian rhythm to a risk of mood disorders, neuroscientists are now proposing that these disruptions define a specific form of depression that they call "circadian depression." First conceptualized in 2021, the body-clock subtype may affect about 1 in 4 people with severe, recurrent or persistent depression, the researchers estimate.

In their new study, published Wednesday (Oct. 21) in The British Journal of Psychiatry, the team identified the subtype in about 2,600 people out of over 11,000 evaluated.

"Circadian depression is a biologically informed subtype," said study co-author Emiliana Tonini, a neuroscientist at the University of Sydney. "Unlike subtypes defined mainly by symptoms, the core feature here is a disturbed circadian system, which common antidepressants may not fully address," Tonini told Live Science in an email.

The researchers think treatments that target the sleep-wake system, such as the sleep hormone melatonin or bright light therapy, might be beneficial for people with this subtype. However, because the subtype is still a proposal and not formally established yet, other experts say that further research is needed before the findings can inform clinical practice.

More than just bad sleep

Tonini and her team analyzed data from 11,380 adults ages 18 to 90 who took part in the Australian Genetics of Depression Study (AGDS), a nationwide study exploring how genes and life experiences influence depression and responses to treatment. They classified participants under the "circadian" umbrella if they had at least three of six features: seasonal mood swings, late sleep schedules, social jet lag (a mismatch between sleep routine during workdays and free days), night-owl habits, excessive sleep (hypersomnia), and fatigue upon waking.

A total of 2,604 people fit the proposed subtype. Compared with others in the AGDS cohort, this group was younger and developed depression earlier in life — around 19, compared with about 23 for the rest of the cohort.

The group also skewed female, and individuals reported greater psychological distress, frequent suicidal thoughts and more physical complaints than people who didn't fit the proposed subtype. Some experienced weight gain during depressive episodes and symptoms resembling hypomania, a revved-up state of elevated mood and energy that's milder than full-blown mania.

However, having this constellation of symptoms doesn't mean someone's biological clock is disrupted, said Brant Hasler, a psychologist and sleep researcher at the University of Pittsburgh who was not involved in the study. The researchers relied on the participants' self-reports of their sleep patterns; that data correlates only modestly with direct measures of circadian timing, such as measurements of melatonin in saliva, he said in an email.

"One can identify as an evening-type, and report later sleep timing, and still have physiological circadian timing that is not particularly delayed," he said.

So, in addition to checking symptoms, the team hunted for genetic clues underlying the proposed subtype. They analyzed DNA from participants' saliva samples and calculated "polygenic risk scores," which add up the influence of thousands of different genetic variants to estimate how likely someone is to develop a given condition.

The body's sleep-wake cycle is largely controlled by a hub of cells within the hypothalamus (red). (Image credit: SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY via Getty Images)

"Mental health conditions are shaped by hundreds or thousands of variants that each add a small amount of risk, so everyone carries a unique 'portfolio' of risk," Tonini explained.

People in the circadian group had a higher genetic risk for depression, anxiety, attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder, the analysis suggested. They also had a greater genetic risk of higher body weight, insulin resistance, inflammation, insomnia and late-night sleep habits, compared with the other study participants.

This suggests "circadian depression is more than just 'depression with bad sleep,'" Tonini said. "It involves a mix of metabolic, inflammatory, circadian, and mood-related processes."

Could this change depression treatment?

The researchers looked at the participants' past experiences with antidepressants, finding that the circadian group reported less benefit from common medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). Common examples include the SSRI Lexapro and the SNRI Cymbalta.

The circadian group also experienced more side effects from these treatments, such as drowsiness, nausea, anxiety and weight gain.

"If circadian disruption is a core biological mechanism in these individuals, treatments that fail to address those abnormalities may naturally be less effective," said Dr. Ruth Benca, a psychiatrist and sleep researcher at Wake Forest University School of Medicine who was not involved in the study. However, Benca cautioned that body-clock disruption may not be the only reason standard drugs fall short for these patients.

"People with more pronounced circadian disturbances often have more severe illness and other psychiatric conditions, which can contribute to treatment resistance," Benca told Live Science in an email.

Even so, tracking sleep, measurements of circadian rhythm, and seasonal shifts in mood could help clinicians identify at-risk patients earlier and select more effective treatments sooner in the course of illness, Benca suggested. "Potential approaches include behavioral routines, structured sleep schedules, or chronotherapy," in which the timing of medication or light exposure is strategically coordinated with internal body rhythms, she added.

Clinical trials are still needed to draw firm conclusions about potential treatments, Tonini noted. The findings also must be validated in broader populations, since the study drew on a single Australian cohort and its genetic analysis included only people of European ancestry.

For now, "the study is an important step toward a more personalized treatment approach," she said.

This article is for informational purposes only and is not meant to offer medical advice.

See how much you know about the most complex organ in the human body with our brain quiz!

'> Could 'body clocks' play a role in depression? Study proposes a new 'circadian' subtype
  • Meet Sky Dragon, the giant 10-person 'flying taxi' that just passed its first flight test in China
  • Flying cars once seemed like the stuff of science fiction. But Tesla's recent demonstration, which showed the company's Rocket Roadster model briefly flying, has reignited the conversation about whether flying cars could soon become a reality.

    The technology behind flying cars is continuing to advance, with companies developing vehicles that combine elements of traditional cars, helicopters, electric aircraft, and — in Tesla's case — rockets. Many of these designs use electric vertical-takeoff-and-landing technology, which allows them to lift off and land without a runway by using multiple rotors or propellers to generate lift. Advances in battery technology, autonomous flight systems and computer-assisted navigation are helping to make these vehicles seem more feasible. But challenges remain, including questions surrounding passenger safety, affordability, and the need for regulations and laws and infrastructure for the widespread use of these vehicles.

    Tesla says production of its new "flying car" is scheduled for 2028, but the company is notorious for not meeting its proposed deadlines. So do you think flying cars could actually be available to the public within the next five years? Or are we still a long way from turning this science fiction fantasy into reality? Cast your vote in our poll, and share your thoughts in our comments section.

    '> Will Tesla's 'flying car' ever hit the market, or is it a load of compressed air?

    The magnitude 7.7 quake hit on March 28, 2025, near the city of Mandalay and shook buildings as far away as Bangkok, 830 miles (1,330 kilometers) away. The death toll was at least 3,700 people. New research that used detailed satellite data and a one-of-a-kind video of the ground rupturing reveals that the fault had a twisty, almost helical shape, which affected the shaking.

    The Sagaing Fault in Myanmar that triggered the quake is analogous to many strike-slip faults worldwide that threaten population centers, said Alice-Agnes Gabriel, a geophysicist at the Scripps Institution of Oceanography at the University of California, San Diego and co-author of the new research, which was published Oct. 14 in the journal Nature Communications. This includes California's San Andreas Fault, which is similarly tilted and likely capable of generating a 7.8 magnitude earthquake. Studying what happened as the ground ruptured near Mandalay can reveal what might occur in future earthquakes on similar faults, Gabriel told Live Science.

    "The idea is, we cannot predict when and where an earthquake might happen" along a particular fault, she said, "but we may be able to predict certain aspects of it."

    Gabriel uses powerful supercomputers to model earthquake scenarios, but these scenarios are only as good as the data that goes into them. In the case of the Myanmar quake, the researchers had a unique piece of data to ground-truth their model on: a security video of the ground cracking as the fault ruptured. This phenomenon had not been captured on video before.

    Damage from the magnitude 7.7 earthquake that hit on March 28, 2025, near the city of Mandalay. (Image credit: Photo(s) taken by Dr. Tha Zin Htet Tin of East Yangon University)

    The researchers' models revealed that the fault is not a vertical plane under the ground. Instead, the surface dips west on the northern end of the fault, becomes vertical in the middle, and then dips eastward at the southern end, they found.

    In general, more shaking occurs in the direction in which a fault line dips, Gabriel said. In the case of the San Andreas Fault, the dip is inland, toward California's high desert — an area that's less populated than coastal regions on the other side of the fault. This means that, if the Big One acts similarly to the Myanmar quake, the high desert side of the fault will experience more intense shaking than the coastal side. The San Andreas Fault has also built up strain for over a century, so the researchers believe it could act in a similar way to the Sagaing Fault.

    However, everyone near a dangerous fault should still prepare for major shaking, Gabriel warned, because small local variations, like how much sediment has accumulated over the bedrock in an area, can make a difference in how bad the ground movement gets. Los Angeles, for example, sits on a sediment-filled basin that would jiggle like jelly in a large quake.

    The researchers also investigated whether they could have predicted aspects of the Mandalay quake from monitoring data they had available from before the quake. They knew that the Sagaing Fault had been "locked" in certain segments, meaning that while the two tectonic plates on each side of the fault were moving, the rocks at the fault line were jammed against each other. These locked segments had been accumulating strain for 186 years.

    The researchers found that they could predict the path, shape and speed of the rupture on the Sagaing Fault in Myanmar with details available prior to the quake, such as the detailed shape of the fault deep underground and how long sections had been locked. Similar predictions could be made for the San Andreas and other important faults. Previous studies have also shed light on other aspects of the fault, such as its simplicity and maturity, that could inform what might happen at other faults around the world.

    Researchers are currently working to update their model of what the Big One would look like on the San Andreas. The results of the update will be shared to help the public prepare, inform building codes and educate emergency managers.

    "This really shows how we can use this long-term fault-monitoring data," Gabriel said.

    '> Devastating 2025 Myanmar earthquake sheds light on how the 'Big One' could play out in California

    The supernova, named AT 2026abck, dates to around 1.15 billion years after the Big Bang, when the universe was less than one-tenth of its current age and bursting with massive stars flickering into life. The massive exploding star violently released its light over 12.5 billion years ago, according to the researchers — so long ago that the distance between us has effectively ballooned sixfold due to the expansion of the universe.

    The discovery was described in a paper that was uploaded to the preprint server arXiv Sept. 29 and has not yet been peer reviewed. According to the study authors, this ancient speck of light is stupendously bright.

    "At its peak, the supernova is about 8 billion times the brightness of the sun … almost as bright as the whole Milky Way Galaxy," study co-author Xiaohui Fan, an observational cosmologist and professor of astronomy at the University of Arizona, told Live Science via email. "Over the course of the explosion, it radiates the energy that the sun will radiate over about 2 billion years."

    A beacon from the beginning of space-time

    The newly discovered supernova shines brilliantly at over 30,000 degrees Fahrenheit (16,000 degrees Celsius). Its incandescent shell of ejected material has billowed to a radius of approximately 46 astronomical units ‪—‬ about 46 times the distance between Earth and the sun, or about as far as Pluto swings at its farthest point from the sun.

    The supernova's host galaxy, designated ID101411, holds about 6.3 billion solar masses and is "forming new stars more than ten times faster than our Milky Way," first author Mingyang Zhuang, an observational astrophysicist at the University of Illinois Urbana-Champaign, told Live Science via email.

    As with other early galaxies, ID101411 is deficient in metals, meaning any elements heavier than hydrogen and helium, because not enough time had passed to create those heavier elements in the forges of massive stars and their apocalyptic explosions.

    An illustration of a supernova erupting when the universe was just 730 million years old. (Image credit: NASA, ESA, CSA, STScI, L. Hustak (STScI))

    The study authors estimate that they observed the supernova as it would have looked just four to 10 days after it exploded. Although this is relatively common, spotting one at such an incredible distance "is extremely rare," Zhuang emphasized. "You have to observe the exact same tiny patch of sky repeatedly with [JWST], and the explosion has to happen at the right moment. We were lucky."

    There's another layer of luck that made the discovery even more remarkable: It was observed without the aid of a cosmological quirk called gravitational lensing — a phenomenon predicted by Einstein in which the gravity of a massive object in space bends and magnifies the light emitted by objects behind it.

    "Most supernovas this far away were found with help from a massive foreground galaxy cluster acting as a natural magnifying glass," Zhuang explained. "It's the most distant one we've actually seen appear."

    This supernova was discovered as part of the NEXUS Treasury program, in which JWST intermittently scours patches of the sky for ancient explosions. It had previously observed the explosion's host galaxy over the past few years and finally witnessed the supernova on Aug. 7 of this year.

    An explosion in slow motion

    Intriguingly, the star had not yet exploded in JWST's previous viewing, on May 28, 2026, meaning that 71 days passed on our Earthly clocks, even though only about 12 days passed in the supernova's own time frame.

    This highlights a mind-bending cosmological effect: The universe's expansion doesn't just stretch space; it slows down time from our perspective.

    "Because the universe has expanded since this light was emitted, everything about this explosion appears to us in slow motion, about six times slower than it actually happened," Zhuang said. "Changes that took one week at the supernova take about six weeks to unfold from our point of view."

    Mysteries still remain about the nature of this ancient explosion that shone so brilliantly we can observe it across nearly the entire universe.

    Rather than a conventional core collapse supernova ‪—‬ in which a star between approximately eight and 50 times the mass of the sun exhaust its nuclear fuel and suffers a rapid core collapse and subsequent explosion ‪—‬ the recently discovered supernova may be one of the universe's rarest, most powerful explosions, the study authors said. Known as a superluminous supernova, this type of explosion releases tens or hundreds of times more energy than conventional supernovas. Whether the explosion continues to heat up or starts to cool could reveal exactly what is happening in its environment and what caused it, the team said.

    "Our interpretation is still preliminary," Zhuang concluded. "Follow-up observations will tell us more about exactly what kind of explosion this was."

    How well do you know our home galaxy? Find out with our Milky Way quiz!

    '> The James Webb telescope is watching one of the earliest supernovas in the universe unfold

    The Voynich manuscript is a medieval codex made up of leaves of parchment carbon-dated to the early 15th century. Its 240 pages are covered with about 38,000 words of a unique script called "Voynichese" along with illustrations of people, plants and astrological symbols. Also known as the Beinecke Cipher manuscript, the document was initially owned by a Holy Roman emperor and was purchased by Wilfrid Voynich in 1912. Since 1969, the manuscript has been in the collection of Yale University's rare book library. Experts have unsuccessfully tried to decipher the manuscript for more than a century.

    "We don't know if it's a code," Lisa Fagin Davis, study co-author and executive director of the Medieval Academy of America, told Live Science. "But there are some odd characteristics of the Voynich manuscript in terms of its physical structure."

    When doing research on the number of scribes who copied the document, Davis realized from the handwriting that the manuscript's pages alternate in ways that don't make sense. In addition, she said, "there are several examples where the image goes off the page in the middle and comes out on the other side, even though there are a bunch of pages in between."

    In a study published Monday (Oct. 19) in the journal Digital Medievalist, Davis and co-author Colin Layfield, an information systems researcher at the University of Malta, suggested that the inconsistent structure of the enigmatic manuscript is the result of someone mis-binding a manuscript they were unable to read.

    a series of illustrations of how a medieval book was bound

    An illustration of how the Voynich manuscript may have been bound incorrectly. (Image credit: Quinn Reynolds for Live Science)

    Medieval manuscripts were made up of rectangular sheets of parchment (animal skin), typically folded in half to produce what experts call a bifolium. Around five bifolia would typically be nested together, creating what experts call a quire. Then, a stack of quires would be bound together along the spine to create a book. However, Davis and Layfield suggested that the Voynich manuscript was intended to be a stack of singulions — a series of loose bifolia never meant to be bound together as a quire or a book.

    This is not the first time a researcher has suggested the Voynich manuscript has pages out of order. But Davis and Layfield analyzed the graphic properties of the untranslated document to see if their hypothesis made sense.

    "We're viewing it as a text and assuming it has a message," Layfield told Live Science, which means it should be possible to statistically compare blocks of text to see if they're similar or disconnected. Layfield used a technique called latent semantic analysis (LSA), which is a natural language processing technique invented in the late 1980s to find hidden patterns in texts.

    LSA is particularly useful for small sets of data, Layfield explained. "Modern AI techniques need ridiculous amounts of data to train on, which we just don't have. We've got just 35,000 or so words. That's it." The researchers' LSA analysis of the Voynich manuscript revealed that some pages had low similarity, suggesting they may not have gone together, while others had high similarity, bolstering the idea that they were supposed to be read together.

    By looking at the Voynich manuscript as a collection of singulions, Davis and Layfield solved some of the nagging issues with the document.

    "When you start to think about it in the context of the other strange features of the manuscript, all of those problems are resolved," Davis said. "It solves the problem of each scribe writing one sheet. It solves the problem of the images crossing the gutter."

    This means that any previous work on the Voynich manuscript that assumes it was ordered correctly now needs to be reconsidered, she said, but it also means there is new progress on the book.

    "This work helps us think about whether there's actual meaning underneath it all," Davis said. "It doesn't get us there," she said about a definitive translation, "but it moves the ball because you can't make sense out of a book where all the pages are mixed up."

    Davis is optimistic that someone will crack the Voynich mystery, in part because a similar modern puzzle known as Cain's Jawbone has been successfully deciphered by a handful of people. This devilishly difficult linguistic puzzle from the 1930s consists of 100 pages of a murder mystery arranged in the wrong order. Due to the unique nature of the text and its vague, stylized language, even AI has failed to solve it.

    "We have some ideas for other work we want to do," Davis said. For example, there's a large water stain in the upper margin of some of the pages of the Voynich manuscript. "The stain should be symmetrical from one page to the next but it's not. That also supports the idea that the manuscript is bound out of order."

    Davis and Layfield are thinking about ways to compare the stain shapes across the pages, as that may help them reorder the incorrectly organized pages.

    See if you know what these mysterious artifacts are with our archaeological fragments quiz!

    '> Undeciphered Voynich manuscript may have been bound out of order, study finds
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